Separation Sciences

The very first GC-MS was a GC-TOFMS which was built in 1947. The information it provided was much too large to record, and it was not until the mid-1990s when LECO introduced the first fast GC-TOFMS, that GC-TOFMS became a useable tool for researchers and analysts. Followed a few years later by LECO’s introduction of the first GCxGC-TOFMS.

Today, LECO’s Separation Science products are recognized across the globe as leading advanced technology innovations in TOFMS Mass Spectrometry and Comprehensive two-dimensional Chromatography.

Examples Of LECO Separation Science Applications


Comprehensive Two-Dimensional Gas Chromatography (GC×GC) has proven to be an extremely valuable analytical technique for the petroleum industry due to its ability to substantially increase the chromatographic peak capacity beyond that of traditional single-dimension gas chromatography. Pairing GC×GC with Time-of Flight Mass Spectrometry (TOFMS) provides unsurpassed characterization capabilities due to the separation power of GC×GC and the ability of TOFMS to provide rich data.

Food Testing

The characterization and safety testing of food and food constitutions can be extremely challenging depending on the complexity and the matrix. The LECO GCxGC TOFMS technology provides a highly powerful separation and remarkable identification allowing for improved workflows. More insights thanks to the advanced technology in combination with LECO’s ChromaTOF® brand software deconvolution algorithm and advanced data analysis tool will improve your Food Quality & Safety Testing and Food R&D. Here we demonstrate the aroma analysis of two types of coffee and coffee packaging and filter leachates.

Perfume And Cosmetics

LECO‘s GCxGC-TOFMS is a valuable asset in the production of cosmetics and perfumes that align with Islamic principles. It can be used to identify the ingredients and detect any prohibited substances such as alcohol or non-halal animal-derived ingredients.

Environmental Analysis

Microplastics are an emerging pollutant which are widely distributed in the environment. Understanding the impact of their growing prevalence on the environment and human health is an important field of research. LECO‘s GCxGC-TOFMS can be used to monitor environmental pollution and air and water quality thus aiding to enforce regulations and ensure the preservation of our environment.


LECO’s key advantage is the ability to identify and discover more metabolites than other similar technologies. Our speed of full-scan acquisition is unrivaled, and when combined with the power of LECO’s ChromaTOF® brand software deconvolution algorithm, allows an unprecedented characterisation of the biological systems under study. Our instrumentation has been validated by the industry‘s most demanding researchers.

Extractables And Leachables

The characterization of extractable and leachable components from a wide range of materials is an important area of research. Information about extractable and leachable components from packaging and delivery devices for pharmaceutical products is a particular area of growing interest. Analytical testing results on this topic are part of many regulatory submission requirements to the FDA, such as USP 1663.