GCxGC („GC by GC“), also known as Comprehensive Two-Dimensional Gas Chromatography, is a powerful analytic technique that utilizes two columns of differing phase selectivity connected by a modulation device. The set-up of GCxGC improves peak capacity, resolution, and detectability. On average, a GCxGC analysis has five times the sensitivity and gains three times the number of compound identifications of typical GC-MS runs.

As a technique that has been around for over 25 years, some may argue that the technique has been over-hyped and a complicated research tool that doesn’t fit into routine analytical laboratories. However, several routine validated GCxGC methods have demonstrated that the technique is accurate, precise, and robust. Research has shown the benefits of GCxGC in a wide variety of applications (e.g. environmental, metabolomics, petroleum, food safety, fragrance). The benefits include increased peak capacity (i.e. resolution), structured two-dimensional chromatograms (i.e. contour plots), and sensitivity enhancement.

The merits of GCxGC as a separation science are clear, but how will it benefit a routine laboratory? Multiple analyte classes can be combined into a single analysis to save instrument and sample preparation time. Manual review time for non-target screening methods can be reduced with the increased peak resolution of a GCxGC analysis by creating a better library match leading to faster, more confident peak identification. Sample characterization is improved with a GCxGC analysis which increases confidence in decisions based on analytical results. The extra resolution afforded by the GCxGC analysis allows the use of more economical detectors, like the flame ionization detector (FID) or electron capture detector (ECD).

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Portfolio přístrojů

Pegasus Two-Dimensional Gas Chromatograph
Pegasus BT 4D

GCxGC Time-of-Flight Mass Spectrometer

Pegasus High Resolution two-dimensional gas chromatograph
Pegasus GC-HRT 4D

High Resolution GCxGC-TOFMS

QuadJet Mass Spectrometer
QuadJet SD

Flame Ionization Detection meets GCxGC

Pegasus BT4D with Paradigm Modulator
Paradigm Flow Modulator and Shift Flow Splitter

Improve GC peak capacity without sacrificing accuracy

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Benefits of GCxGC for a Routine Laboratory

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Poznámky k aplikaci

Zjistěte více o našich řešeních pro GCxGC s naší knihovnou souvisejících poznámek k aplikacím.

209-200-172 Dual-Detection of Plastics-Derived Pyrolysis Oil

Data from a single injection of plastics-derived pyrolysis oil using GCxGC with reverse fill-flush modulator and flow splitter is explored.

209-200-173 Reformulation of Perfume Samples with GCxGC-TOFMS/FID

Chromatograms of perfume sample obtained with use of reverse fill-flush modulator and flow splitter are analyzed

209-200-175 Simple Group-type Analyses of Aviation Fuels

Flow modulation provides high accuracy group-type analyses for traditional fuels and emerging alternatives.

209-200-174 GCxGC Coelution Data Detection with RFF Modulator

Data demonstrating how Paradigm reverse-fill flush modulator and Shift flow splitter enhance GCxGC detection accuracy in fragrance samples.

203-821-667 Aroma Compounds Pumpernickel Bread

Aroma Compounds Pumpernickel Bread

Browse 35 additional application notes for GCxGC.

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