Metabolomics

LECO’s high-resolution mass spectrometry and GC×GC platforms provide comprehensive metabolite profiling, helping researchers discover biomarkers, understand disease, and analyze complex biological samples.

203-821-662
Early Type 2 Diabetes prediction can be facilitated by the implementation of a metabolomics method for the identification of T2DM biomarkers. A complete automated derivatization workflow is explored.
203-821-422
Liver disease affects more than 800 million people worldwide causing at least 1.5 million deaths annually. Mice provided a reliable model for detection of polychlorinated biphenyls associated with non-alcoholic fatty liver disease.
This curated compilation of articles and papers illustrates how Time-of-Flight Mass Spectrometry is advancing metabolomics research. Laboratories around the world use the Pegasus series of mass spectrometers to help their data soar.
Copresenters Renee Cataneo & Mayur Mundada [Menssana Research Inc.] discuss data obtained through GCxGC TOF-MS analysis of breath samples. Originally presented 20 September 2012.
JP-BA14-LPSS-157
Breath volatomes were analyzed via GCxGC-TOFMS to demonstrate possible future of metabolomic studies.
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Jean-Francois Focant from the University of Liege (Belgium) discusses utilizing two-dimensional gas chromatography to study volatile compounds in breath samples of asthma patients.
DA-MBX25-LPSS-340
The development of a selective complementary, non-invasive test for the early detection of prostate cancer would be beneficial for early medical intervention, periodic monitoring, and treatment. The goal of this study was to develop an analytical...
415-956-002
Dr. Heather Bean (Arizona State University) discusses using GCxGC-TOF MS to detect and phenotype infections directly from lung samples.
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203-821-447
This application note demonstrates the value of both electron impact ionization (EI) and chemical ionization—high-resolution time-of-flight mass spectrometry (HR-CI) in identifying analytes in complex metabolomic samples. The complementary use of ...
SS-ASMS20-LPSS-002
Tile-based Fisher ratio (F-ratio) analysis is used to discover and quantify metabolites in Argentinian pacu fish, using data collected by comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GCxGC-TOFMS) ...
JH-ISCC13-LPSS-109
Rodent liver samples were analyzed to create a standardized GCxGC method and software reference.
Vladimir Tolstikov, PhD, from Eli Lilly discusses utilizing High-Resolution Gas Chromatography Mass Spectrometry in Metabolomics analyses. Accompanying slides are available.
Vladimir Tolstikov, PhD, from Eli Lilly discusses utilizing High-Resolution Gas Chromatography Mass Spectrometry in Metabolomics analyses.
DA-PCON15-LPSS-165
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An Online Guide for Optimizing Comprehensive Two Dimensional GC Separations